Department of Biochemistry
Leading the way in Biomedical Sciences
Assistant Professor INOUE Takao
Ph. D. (University of Washington, Seattle)
RESEARCH INTERESTS
I am using C. elegans genetics to address important questions in signal transduction and development. Major areas of interest include:
* Mechanism and function of Wnt signalling through the Ryk receptor tyrosine kinase
* Understanding how gene regulatory networks specify cell fates during organogenesis
SELECTED PUBLICATIONS
1. Inoue T and Sternberg PW. (2010) C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis. Dev Biol. 338(2):226-36
2. Green JL, Inoue T and Sternberg PW. (2008) Opposing Wnt pathways orient cell polarity during organogenesis. Cell. 134: 646-656.
3. Inoue T, Ailion M, Poon S, Kim HK, Thomas JH and Sternberg PW. (2007) Genetic Analysis of Dauer Formation in Caenorhabditis briggsae. Genetics. 177: 809-818.
4. Inoue T, Wang M, Ririe T, Fernandes J, and Sternberg PW. (2005) Transcriptional network underlying C. elegans vulval development. Proc. Natl. Acad. Sci., USA 102: 4972-4977 (In Gene Regulatory Networks Special Feature).
5. Inoue T, Oz HS, Wiland D, Gharib S, Deshpande R, Hill RJ, Katz WS, and Sternberg PW. (2004) C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN- 17/Frizzled in Wnt signaling. Cell. 118: 795-806.
