Dr.
SHEN Han-Ming
Associate Professor
Tel: (65)-6516-4998
Fax: (65)-6779-1489
Email: 
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| Education |
| Bachelor
of Medicine |
1985 |
Zhejiang
Medical University, China |
| Master
of Medicine |
1988 |
Zhejiang
Medical University, China |
| PhD |
1996 |
National
University of Singapore |
| |
|
|
| Professional
Appointment |
| Oct
2008 to present |
|
Member,
NUS Graduate School for |
| |
|
Integrative
Sciences and Engineering (NGS) |
| |
|
|
| July
2007 to present |
|
Associate
Professor with tenure, |
| |
|
Dept.
of EPH, Yong Loo Lin School of Medicine, NUS |
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|
|
| Dec
2002 to June 2007 |
|
Assistant
Professor |
| |
|
Dept.
of COFM, Yong Loo Lin School of Medicine, NUS |
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|
|
| Apr
2002 to July 2003 |
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Exchange
Scientist |
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National
Cancer Institute (NCI), NIH, USA |
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|
|
| Feb
2001 to Nov 2002 |
|
Research
Fellow |
| |
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Dept.
of COFM, Faculty of Medicine, NUS |
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|
|
| Dec
1996 to Jan 2001 |
|
Postdoctoral
Fellow |
| |
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Dept.
of COFM, Faculty of Medicine, NUS |
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|
|
| Main
Research interests |
|
|
| (1) |
Involvement
of Reactive Oxygen/Nitrogen Species and Oxidative |
| |
Stress
in Cell Death Signaling Pathways (Apoptotic and Non-Apoptotic
Cell Death) |
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|
| (2) |
Autophagy
and Cell Death |
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|
(3) |
Antioxidants
and Natural Products as Anti-Cancer Agents |
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|
| Selected
Publications (click
here for the full list) |
| (1)
Huang Q, Wu YT, Tan HL, Ong CN, Shen HM A novel
function of PARP-1 in modulation of autophagy and necrosis under
oxidative stress. Cell Death and Differentiation (Manuscript
accepted for publication on Sept 15, 2008). |
| |
|
| (2)
Wu YT, Tan HL, Huang Q, Kim YS, Pan N, Ong WY, Liu ZG, Ong CN,
Shen HM. Suppression of Autophagy via Inhibition
of Lysosomal Function Contributes to zVAD-Induced Necrotic Cell
Death. Autophagy 4:457-466, 2008. |
| |
|
| (3)
Zhou J, Lu GD, Ong CS, Ong CN, Shen HM*. Andrographolide
Sensitizes Cancer Cells to TRAIL-Induced Apoptosis via p53–Mediated
DR4 Up-regulation. Mol Cancer Therap 7:2170-2180, 2008. |
| |
|
| (4)
Wu YT, Zhang SY, Kim YS, Tan HL, Whiteman M, Ong CN, Liu ZG,
Ichijo H, Shen HM*. Signaling Pathways from
Membrane Lipid Rafts to JNK1 Activation in Reactive Nitrogen
Species-Induced Non-Apoptotic Cell Death. Cell Death and Differentiation
15:386-397, 2008. |
| |
|
| (5)
Shi J; Shen HM*. Critical role of Bid and Bax
in I3M-induced apoptosis in human cancer cells. Biochem Pharmacol
75:1729-1742, 2008. |
| |
|
| (6)
Zhang, S.Y.; Lin Y; Kim, Y.,S.; Liu, Z.,G.; Ong, C.N.; Shen,
HM*. c-Jun N-terminal Kinase Mediates Hydrogen Peroxide-Induced
Cell Death via Sustained Poly(ADP-ribose) Activation. Cell Death
Differ 14:1001-1010; 2007 |
| |
|
| (7)
Shi RX, Huang Q, Zhu X, Ong YB, Zhao B, Lu J, Ong CN, Shen
HM*. Luteolin sensitizes the anticancer effect of cisplatin
via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and
stabilization. Mol Cancer Ther. 6:1338-1347; 2007 |
| |
|
| (8)
Huang Q, Shen HM, Shui G, Wenk MR, Ong CN.
Emodin Inhibits Tumor Cell Adhesion through Disruption of the
Membrane Lipid Rafts-associated Integrin Signaling Pathway.
Cancer Res 66:5807-5815; 2006. |
| |
|
| (9)
Shen HM; Pervaiz, S. TNF-Receptor Superfamily-Induced
Cell Death: Redox-Dependent Execution (invited review) FASEB
J. 20:1589-1598; 2006. |
| |
|
| (10)
Zhang, S.; Li, Z.; Wu, X.; Huang, Q.; Shen, H. M.;
Ong, C. N. Methyl 3-indolylacetate inhibits cancer cell invasion
by targeting the MEK1/2 - ERK1/2 signaling pathway. Mol Cancer
Therapeutic 5:3285-3293 (2006). |
| |
|
| (11)
Shen, HM*; Liu, Z.G. JNK Signaling Pathway
is a Key Modulator in Cell Death Mediated by Reactive Oxygen
and Nitrogen Species (review). Free Radic. Biol. Med. 40:928-939;
2006. |
| |
|
| (12)
Shi, R. X.; Ong, C. N.; Shen, HM*. Protein
kinase C inhibition and x-linked inhibitor of apoptosis protein
degradation contribute to the sensitization effect of luteolin
on tumor necrosis factor-related apoptosis-inducing ligand-induced
apoptosis in cancer cells. Cancer Res. 65:7815-7823; 2005. |
| |
|
| (13)
Won, Y. K.; Ong, C. N.; Shen, HM*. Parthenolide
sensitizes ultraviolet (UV)-B-induced apoptosis via protein
kinase C-dependent pathways. Carcinogenesis. 26:2149-2156; 2005. |
| |
|
| (14)
Zhang, S.; Won, Y. K.; Ong, C. N.; Shen, HM*.
Anti-cancer potential of sesquiterpene lactones: bioactivity
and molecular mechanisms (invited review). Curr. Med. Chem.
Anticancer Agents. 5:239-249; 2005. |
| |
|
| (15)
Shen, H. M.; Lin, Y.; Choksi, S.; Tran, J.;
Jin, T.; Chang, L.; Karin, M.; Zhang, J.; Liu, Z. G. Essential
roles of receptor-interacting protein and TRAF2 in oxidative
stress-induced cell death. Mol. Cell Biol. 24:5914-5922; 2004. |
| |
|
| (16)
Zhang, S.; Lin, Z. N.; Yang, C. F.; Shi, X.; Ong, C. N.; Shen,
HM*. Suppressed NF-kappaB and sustained JNK activation
contribute to the sensitization effect of parthenolide to TNF-alpha-induced
apoptosis in human cancer cells. Carcinogenesis. 25:2191-2199;
2004. |
| |
|
| (17)
Shi, R. X.; Ong, C. N.; Shen, HM*. Luteolin
sensitizes tumor necrosis factor-alpha-induced apoptosis in
human tumor cells. Oncogene. 23:7712-7721; 2004. |
| |
|
| (18)
Won, Y. K.; Ong, C. N.; Shi, X.; Shen, HM*.
Chemopreventive activity of parthenolide against UVB-induced
skin cancer and its mechanisms. Carcinogenesis. 25:1449-1458;
2004. |
| Members
of the Cancer Cell Biology Lab |
| (1) |
Dr.
SHEN Han-Ming |
PI |
| (2) |
Dr.
HUANG Qing |
Postdoctoral
Fellow |
| (3) |
ONG
Yeong-Bing |
Lab
Officer |
| (4) |
TAN
Hui-Ling |
Research
Assistant |
| (5) |
Zhao
Wei |
Research
Assistant |
| (6) |
ZHOU
Jing |
PhD
candidate |
| (7) |
WU
You-Tong |
PhD
candidate |
| (8) |
NG
Shukie |
Postgraduate |
| (9) |
ONG
Chye-Sun |
PhD
candidate (part-time) |
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