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My lab studies antiviral cellular immune responses. We are designing and synthesizing HLA tetramers specific for epitopes from Epstein-Barr virus (EBV) restricted by HLA Class I molecules common in the Singaporean population in order to characterize EBV-specific CD8+ T cell responses quantitatively and functionally. We are collaborating with the Department of Otolaryngology at the National University Hospital to determine whether these EBV-specific T cell responses are associated with the development of nasopharyngeal carcinoma, a tumor that has a peculiar predilection for individuals of Southern Chinese descent.
We also collaborate with the Department of Internal Medicine, Singapore General Hospital, to study the T and NK cell responses directed against cytomegalovirus (CMV) in patients who have atypical clinical presentations of CMV disease.
Finally, we are extremely interested in examining innate immune response mechanisms during cellular infection by dengue virus, and we are actively recruiting individuals into projects in this field.
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Wong J, Rinke Bos and Linda A Sherman (2008) Tumor-Specific CD4+ T Cells Render the Tumor Environment Permissive for Infiltration by Low-Avidity CD8+ T Cells. J. Immunol. 180:3122-3131
Wong J and Siliciano RF (2005) Contribution of virus-like particles to the immunogenicity of human immunodeficiency virus type 1 Gag-derived vaccines in mice. J. Virol. 79:1701-1712
Wong J, Buck CB, Shen X and Siliciano RF (2004) An evaluation of enforced rapid proteasomal degradation as a means of enhancing vaccine-induced CTL responses. J. Immunol. 173:3073-3083
Shen X, Wong J, Buck CB, Zhang J and Siliciano RF (2002) Direct priming and cross-priming contribute differentially to the induction of CD8+ CTL following exposure to vaccinia virus via different routes. J. Immunol. 169:4222-4229
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