Department of Microbiology

Lu Jinhua


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Lu Jinhua BA, PhD

Associate Professor, Department of Microbiology
Supervisor, DNA Sequencing and in situ Hybridization Core Facility, National University Medical Institutes

Tel: +65 6516 3277
Email: miclujh@nus.edu.sg

Research in this group focuses on innate immunity. Earlier work emphasized on host recognition of carbohydrate structures on microbes using lectins including collectins and ficolins, leading to microbial killing and clearance. More recent work focus on microbial interaction with macrophages and dendritic cells and how these cells employ phagocytic and Toll-like receptors (TLRs) for pathogen capturing and sensing. We are intensely interested in how phagocytic receptors and TLRs cross-talk to modulate the immunostimulatory and tolerogenic properties of dendritic cells. Through comparative studies, we investigate the molecular basis of macrophage and dendritic cell functional heterogeneity at different differentiation and activation states. On-going projects include:

Mechanisms of TLR co-operation and activation
Phagocytic receptor signalling in dendritic cells and macrophages
Autocrine regulation of immunostimulatory and tolerogenic properties of dendritic cells
Dendritic cell-based vaccine adjuvant development
The regulatory roles of C1q

Ze HF, Wang XW, Lu JH, Ho B and Ding JL (2008) Elucidating the function of an ancient NF-kB p100 Homologue, CrRelish, in Antibacterial Defence. Infect. Immun. 76:664-670

Ng PM, Le Saux A, Lee CM, Tan NS, Lu J, Thiel S, Ho B and Ding JL (2007) C-reactive protein collaborates with plasma lectins to boost immune response against bacteria. EMBO J. 26:3431-3440

Lu J, Wu X, and Teh BK (2007) The regulatory roles of C1q. Immunobiol. 212:245-252

Cao W, Tan P, Lee CH, Zhang H and Lu J (2006) A Transforming Growth Factor beta-induced Protein Stimulates Endocytosis and Is Specifically Induced in Immature Dendritic Cells. Blood. 107:2777-2785

Sun G, Lu J, Pervaiz S, Gan YH (2006) Caspase-1 dependent macrophage death induced by Burkholderia pseudomallei. Cell. Microbiol. 7:1447-1458

Zhong F, Cao W, Chan E, Tay PN, Cahya FF, Zhang H, Lu J(2005) Deviation from major codons in the Toll-like receptor genes is associated with low Toll-like receptor expression. Immunol. 114:83-93

Cao W, Lee SH, Lu J (2005) CD83 is preformed inside monocytes, macrophages and dendritic cells but it is only stably expressed on activated dendritic cells. Biochem. J. 385:85-93

Chen K, Lu J, Wang L and Gan YH (2004) Enhancement of antigen cross-presentation by heat shock protein 65 in dendritic cells. J. Leukoc. Biol. 75:260-266

Bobryshev YV, Cao W, Phoon MC, Tran D, Chow VTK, Lord RSA and Lu J (2004)Detection of Chlamydia pneumoniae in dendritic cells in atherosclerotic lesions. Atherosclerosis. 173:185-195

Cao W, Bobryshev YV, Lord RSA, Oakley REI, Lee SH and Lu J (2003) Dendritic cells in the arterial wall express C1q: potential significance in atherogenesis. Cardiovasc. Res. 60:175-186

Zhang H, Tay PN, Cao W, Li W and Lu J (2002) Integrin-nucleated Toll-like receptor (TLR) dimerization reveals subcellular targeting of TLRs and distinct mechanisms of TLR4 activation and signaling. FEBS Lett.532:171-176

Li, B, JY New, E H Yap, J Lu, Chan SH and H Hu (2001) Blocking L-selectin and alpha 4-integrin changes donor cell homing pattern and ameliorates murine acute graft versus host disease. Eur. J. Immunol. 31: 617-624

Wang, Q, Lu JH and E L Yong (2001) Ligand-and coactivator-mediated transactivation function (AF2) of androgen receptor ligand-binding domain is inhibited by the cognate hinge region. J. Biol. Chem. 276:7493-7499

Lab Members:
	Jason Goh Wee Kang +65 6516 7208 / 7583 micgwkj@nus.edu.sg
	Linda Wang +65 6516 7208 / 7583 medp1176@nus.edu.sg
	Teh Boon King +65 6516 7208 / 7583 g0500849@nus.edu.ag
	Elaine Lai Min Chern +65 6516 7208 / 7583 micelmc@nus.edu.sg
	Tan Yen Seah +65 6516 7208 / 7583 mictys@nus.edu.sg
	Wang Yinan +65 6516 7208 / 7583 nmiwy@nus.edu.sg
	Edmund Chan +65 6516 7208 / 7583 g0305826@nus.edu.sg