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Lee Yuan Kun BSc (Hons), MSc, PhD

Associate Professor

Tel: +65 6516 3284
Email: micleeyk@nus.edu.sg

Research Interest

Fermentation
Microbial fermentation processes and microbial enzymes in the production of pharmaceutical, food and waste treatment are major research interests of this laboratory.

Microbe-host interactions & probiotics
Probiotcis being defined as microorganisms, which impart beneficial effects to the host, is another major research interest of this laboratory. Cross-talk, which involved cell-cell adhesion and immunoodulation are focuses of the study.

 
Representative Publications

Are A, Aronsson L, Wang S, Greicius G, Lee YK, Gustafsson JA, Pettersson S and Arulampalam V (2008) Enterococcus faecalis from newborn babies regulate endogenous PPARgamma activity and IL-10 levels in colonic epithelial cells. Proc. Natl. Acad. Sci. 105:1943-1948

Chow WL and Lee YK (2007) Free fucose is a danger signal to human intestinal epithelial cells. Br. J. Nutr. 1-6

Chow WL and Lee YK (2006) Mucosal interactions and gastrointestinal microbiota. In: Gastrointestinal Microbiology. Ouwehand A, Vaughan EE ed Taylor & Francis Pp 123-135

Crittenden R, Bird AR, Gopal P, Henriksson A, Lee YK and Playne MJ (2005), Probiotic research in Australia, New Zealand and the Asia-Pacific region. Current Pharmaceutical Design. 11:37-53

Lee YK, Hao WL, Ho PS, Nordling MM, Low CS, Kok TMCM and Rafter J (2005) Human fecal water modified adhesion of intestinal bacteria to Caco-2 cells. Nutr. Cancer 52:35-42

Ho PS, Kwang J and Lee YK (2005) Intrageastric administration of Lactobacillus casei expressing transmissible gastroenteritis coronavirus spike glycoprotein induced specific antibody. Vaccine. 23:1335-1342

Lee YK (2004) Mathematical modelling of intestinal bacteria-host interactions. In: Lactic Acid Bacteria, Microbiology and Functional Aspects, 3rd ed Salminen S, von Wright A, Ouwehand A ed Marcel Dekker Pp 351-364

Lee YK, Ho PS, Low CS, Arvilommi H and Salminen (2004) Long-term colonisation by Lactobacillus casei Shirota is hindered by the slow rate of cell division in the mouse gut. Appl. Environ. Microbiol. 70:670-674

Salminen S, Gorbach S, Lee YK and Benno Y (2004) Human studies on probiotics: What is scientifically proven today? In: Lactic Acid Bacteria, Microbiology and Functional Aspects, 3rd ed Salminen S, von Wright A, Ouwehand A ed Marcel Dekker Pp 515-530

Lee YK, Puong KY, Ouwehand AC and Salmionen S (2003) Displacement of bacterial pathogens from mucus and Caco-2 cell surface by lactobacilli. J. Med. Microbiol. 52:925-930

Seow, S.W., JNB Rahmat, AAK Mohamed, R Mahendran, Lee YK and BH Bay (2002) Lactobacillus species is more cytotoxic to human bladder cancer cells than Mycobacterium bovis (Bacillus Calmette-Guerin). J. Urol. 168:2236-2239

Lee YK, Lim CY, Teng WL, Ouwehand AC, Tuomola FM and Salminen S (2000) Quantitative approach in the study of adhesion of lactic acid bacteria to intestinal cells and their competition with enterobacteria. Appl. Environ. Microbiol. 66:3692-3697

Lee YK, Nomot S, SalminenS and Gorbach S (1999) Handbook of probiotics. John Wiley & Sons Pp 220

Current Projects:

i-arrow Intestinal commensal bacteria
i-arrow Cell adhesion
i-arrow Immunomodulation
i-arrow Signaling pathways
i-arrow Carbohydrate as signaling molecule
i-arrow Probiotics as oral vaccine vector
       

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