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Professor Einar Wilder Smith

Professor & Senior Consultant Neurologist
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
Director, Clinical Neurophysiology, National University Hospital
Chair, Laboratory Research Committee, Department of Medicine
Chair, Chapter of Neurology, College of Physicians, Singapore
Chair, educational committee, Asian Society of Neurologists (ASNA)

Telephone DID: (65)6772 4380
Telefax: (65)6779 4112
Mail to:

Professor Einar Wilder Smith
MBBS (Heidelberg, Ger), MD (Heidelberg, Ger), DTM&H (Lon), FAMS (Neurology)

Clinical Service

I see patients across the whole spectrum of Neurological disorders. Particular interest is in managing patients with peripheral nerve disorders (including nerve entrapments, polyneuropathies), myasthenia gravis, epilepsy and multiple sclerosis.


After graduating in medicine from the University of Heidelberg, Germany 1987, I trained in Neurology and Neurophysiology at the University Hospital Heidelberg, Germany and the Neurology University Clinic in Bern, Switzerland. I obtained my MD from Heidelberg University in 1989 and registration as a Neurologist in 1993. Since 1998 I have worked as a Neurologist in Singapore, first at the Neurology Department of the Singapore General Hospital and from 2000 onwards at the National University Hospital.

Research Interests

My research focus is on peripheral nerve disorders, with an emphasis on improving diagnostics and treatment. Research collaborations are with the Department of plastic and reconstructive surgery, NUHS, Institute for molecular and cell biology, A* Star, the Engineering department as well as the Department of Electrical and Computer Engineering, NUS.
Current projects include Ultrasound assessment of median nerve morphological and blood flow changes after distal radius fracture, assessment of Ulnar neuropathy, treatment of neuropathies using bone marrow derived mononuclear cells in the diabetic neuropathy mouse model, bionic prosthesis for the repair of sciatic nerve lesions in the rat, multimodal analysis of cortical activity in the human brain. My research has provided important clinical and biological insights into peripheral nerve and other neurological disorders. Please refer to the following webpage ( for more information.

Selected Publications

  1. Wilder-Smith EP, GuoY, Chow A. (2009) Stimulated skin wrinkling for predicting intraepidermal nerve fibre density. Clinical Neurophysiology. Apr 15.

  2. Rathakrishnan R, Sidik NP, Huak CY, Wilder-Smith EP. (2009) Generalised convulsive status epilepticus in Singapore: Clinical outcomes and potential prognostic markers. Seizure. 18(3):202-5.

  3. Wilder-Smith EP, Van Brakel. (2008) Nerve damage in leprosy and its management. Nature: Clinical Practice Neurology. 4(12):656-63.

  4. Yeo MVM, Li XP, Shen KQ, and Einar P. V. Wilder-Smith. (2009). Can SVM be used for automatic EEG detection of drowsiness during car driving? Safety Science 47;115-124 .

  5. Wilder-Smith EP, Ng ES (2008). The writing on the wall. The Lancet. 372(9635):344

  6. Shao SY, Shen KQ, Ong CJ, Wilder-Smith EP, Li XP (2008). Automatic EEG Artifact Removal: A Weighted Support-Vector-Machine Approach with Error Correction. IEEE Transactions on Biomedical Engineering, 2008 Oct 3.

  7. Teoh HL, Chow A, Wilder-Smith EP. (2008) Skin wrinkling for diagnosing small neuropathy: Comparison with epidermal nerve density and SSR. J Neurol Neurosurg Psychiatry. 79(7):835-7

  8. Wilder-Smith EP, Chow A. (2006) Comparison of a simple method for quantitation of intraepidermal nerve fibres with a standard image analysis method using hypothenar skin. J Neurology, 253:1011-5. IF 2.778

  9. Wilder-Smith EP, Seet RS, Lim EC (2006). Diagnosing carpal tunnel syndrome—clinical criteria and ancillary tests. Nature: Clinical Practice Neurology. 2:366-374

  10. Van Brakel WH, Nicholls PG, Das L, Barkataki P, Maddali P, Lockwood DN, Wilder-Smith E. (2005) The INFIR Cohort Study: assessment of sensory and motor neuropathy in leprosy at baseline. Lepr Rev., 76:277-95.

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