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Professor Lee Kok Onn

Professor, Yong Loo Lin School of Medicine
Senior Consultant & Head of the Division of Endocrinology, Department of Medicine, NUS

Telephone DID: (65)6772 4341
Telefax: (65)6779 4112
Mail to:

Professor Lee Kok Onn
BSc, MBBCh, MD (Belfast), FRCP(Ed), FRCP(Ire), FRCP, FRACP, FAMS (Singapore)

Clinical Services

As Senior Consultant and Head of the Division of Endocrinology at the Department of Medicine, National University Hospital, I see primarily non-diabetes endocrinology patients with pituitary, adrenal, bone or gonadal disorders.


Obtained B Sc Honours 1st in Physiology, MBBCh, and MD from the Queen's University of Belfast, Northern Ireland. After clinical postings in Belfast, moved to Singapore for further training in Endocrinology. This included training at the Molecular Endocrinology Laboratory (BD Weintraub) at the NIDDK, NIH, Bethesda in 1985-86, the Department of Paediatric Endocrinology (RG Rosenfeld), Stanford University in 1993, and the Department of Endocrinology at Stanford University and the Palo Alto VA Hospital (AR Hoffman) in 2000.

Research Interests

My research has been mainly in the scientific areas of thyrotrophin (TSH), thyrotoxic periodic paralysis (TPP), and the growth hormone (GH)/ insulin-like growth factor (IGF)/ and IGF-binding protein (IGFBP) axis relationship in abnormal states and cancer. Recently my research interest has included ethnic differences in diabetes.

Selected Publications
1. Loke KY, Yap HK, Zhou X, Tan SP, Chao SM, Lee KO (1997). Efficacy and safety of one year growth hormone therapy in steroid dependent nephrotic syndrome. J Pediatrics 130: 793.
2. Ng EH, Ji CY, Tan PH, Lin V, Soo KC, Lee KO (1998) Altered serum levels of insulin-like growth factor binding proteins in breast cancer patients. Ann Surgical Oncology (New York) 5: 194
3. Miao Z-R, Lin TK, Bongso A, Zhou X, Cohen P, Lee KO (1998) Effect of insulin-like growth factors (IGFs) and IGF binding proteins on in vitro sperm function. Clinical Endocrinol 49: 235.
4. Kaulsay KK, Ng EH, Ji CY, Ho GH, Aw TC, Lee KO (1999). Serum insulin-like growth factor binding protein (IGFBP)-6 and prostate specific antigen (PSA) in breast cancer. European J Endocrinol 140: 164.
5. How HK, Yeoh A, Quah TC, Oh Y, Rosenfeld RG, Lee KO (1999). Insulin-like growth factor binding proteins (IGFBPs) and IGFBP-related protein 1(IGFBP-rP1) in cerebrospinal fluid of children with acute lymphoblastic leukemia. JCE&M 84:1283
6. Kaulsay KK, Mertani HC, Lee KO, Lobie PE (2000) Autocrine growth hormone enhancement of mammary carcinoma cell spreading is JAK2 dependent. Endocrinology 141:1571
7. Zhou X, Loke KY, Pillai CC, How HK, Yap HK, Lee KO (2001). Insulin-Like Growth Factors (IGFs) and IGF-Binding Proteins in Short Children with Steroid-Dependent Nephrotic Syndrome on Chronic Glucocorticoids. European J Endocrinol 144: 237.
8. (Li T, Vu TH), Lee KO, Yang YW, Nguyen CV, Bui HQ, Zeng ZL, Nguyen BT, Hu JF, Murphy SK, Jirtle RL, Hoffman AR. (2002) An imprinted PEG1/MEST antisense expressed predominantly in testis and in mature spermatozoa. JBC 277: 13518.

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