Although staff members have been able to actively
develop research on a wide front, the major areas of focus are:
|
Research Projects / Interests
|
Principle Investigator
|
- Ischemic stroke with a focus on establishing an animal model for and biomarker studies of intracranial stenosis.
- The involvement of hydrogen sulfide in ischemic injuries – the therapeutic potential of inhibiting the production of hydrogen sulfide.
- Dementia – postmortem brain and animal model studies.
|  Prof
Wong Tsun Hon,
Peter |
- Pharmacological studies on venoms and toxins from scorpions,
stonefish and snakes in collaboration with the NUS Venom
and Toxin Multidisciplinary Research Group
- Pharmacology of nitric oxide and peripheral nitrergic
transmission involving the nitric oxide
synthase-cGMP transduction system
|
Prof
Gwee Choon Eng,
Matthew |
- Genetic polymorphisms in health and disease / Ethnicity - Drug transporters, ion channels, drug metabolism enzymes.
- Sudden Cardiac Death Syndrome.
- Phase I clinical trials: multiethnic comparisons, ethnic sensitivity
testing.
|
Prof Lee Jon Deoon,
Edmund |
- Neurogenic Inflammation in Acute Pancreatitis
- Chemokines in Ancute Pancreatitis
- Apoptosis of Pancreatic Acinar Cells
|
A/Prof
Bhatia, Madhav |
- Regulation of HERG/IKr channel expression, trafficking
and function
- Hydrogen sulfide regulation of calcium homeostasis in
excitable cells
|
A/Prof Bian Jinsong |
- Genetic polymorphisms in health and disease
- Interindividual/interethnic differences in drug disposition
and response
- Clinical drug development/ Good Clinical Practice
- Bioanalytical method development and validation for the
accurate analyses of drugs and metabolites in biological
fluid for Clinical Therapeutic Drug Monitoring (TDM) and
for Pharmacokinetic studies." and "Pharmacokinetic
(PK), phenotyping and Pharmacodynamic (PD) as well as population
PK and population PD modelling studies of anticancer and
related drugs.
|
A/Prof
Lee How Sung |
- Therapeutic drug monitoring and analyses of drug concentrations
- Clinical pharmacokinetics and population pharmacokinetics
and pharmacodynamics of drugs, mainly antimicrobials, antipsychotics
and others
- indoleamines in blood and platelets of psychiatric patients
- 13C Isotope ratio breath tests for diagnoses of e.g Helicobactor
pylori
- Drug discovery and development - Therapeutic uses of des-aspartate-angiotensin
I in cardiovascular and renal diseases e.g. cardiac hypertrophy,
restenosis and neointima formation, post-infarction cardiac
injuries, glomerulosclerosis and renal failure.
|
A/Prof
Sim Meng Kwoon |
