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General research interests:
- Therapeutic drug monitoring and bioanalyses of drugs and
metabolites concentrations.
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Clinical pharmacokinetics and population
pharmacokinetics and pharmacodynamics of drugs, mainly
anticancer drugs, antipsychotics and antimicrobials.
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Pharmacokinetics of potential new drugs small molecules.
General research projects:
- Bioanalytical method development and validation
for the accurate analyses of drugs and metabolites in biological
fluid for
Clinical Therapeutic Drug Monitoring (TDM) and
for Pharmacokinetic studies.
Pre-clinical pharmacokinetic studies potential new drugs
small molecules.
Methods used are mainly HPLC and LCMSMS.
Team Collaboration:
- Lee How Sung
- Khoo Yok Moi (Sr Lab Technologist)
- Fan Lu (Lab Technologist)
- Wang Lingzhi (NUH)
- Pharmacokinetic (PK), phenotyping and Pharmacodynamic
(PD) as well as population PK and population PD modelling
studies of anticancer and related drugs.
The aim of the projects is to model the population PK/PD
data to obtain the most appropriate models for the prediction
of the optimum dosage regimen of anticancer drug therapy
for each individual patient so as to obtain optimum efficacy
with minimum toxicity.
Team Collaboration (with NUH Department of Haematology
and Oncology):
- Dr. Goh Boon Cher (NUH)
- Dr. Lee Soo Chin (NUH)
- Wang Lingzhi (NUH)
- Lee How Sung
- Khoo Yok Moi (Sr Lab Technologist)
- Fan Lu (Lab Technologist)
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