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Academic Staff
Adjunct Staff
Research Staff
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Current Position
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- Principal Research Scientist,
Department of Clinical Research, Singapore General Hospital
- Adjunct
Assistant Professor, Department of Pharmacology, National
University of Singapore
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Academic Qualifications
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BSc (Biological Sciences) |
1995 |
University of Alberta, CANADA |
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PhD (Pharmacology) |
2003 |
University of Sydney, AUSTRALIA |
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| Research
Interests |
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1. Dementia neurochemistry
2. Genetic and epigenetic factors in neurodegenerative
diseases
3. Interactions among neurotransmission, t protein and
b-amyloid peptide
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Selected Publications |
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Tsang SW, Vinters
HV, Cummings JL, Wong PT, Chen CP, Lai MK.
Alterations in NMDA receptor subunit densities and ligand
binding to glycine recognition sites are associated with
chronic anxiety in Alzheimer's disease. Neurobiol Aging.
2007; In Press
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Tsang SW, Pomakian
J, Marshall GA, Vinters HV, Cummings JL, Chen CP, Wong PT,
Lai MK. Disrupted muscarinic M1 receptor signaling
correlates with loss of protein kinase C activity and
glutamatergic deficit in Alzheimer's disease. Neurobiol
Aging. 2007;28(9):1381-87.
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Lai MK,
Tsang SW, Garcia-Alloza M, Minger SL, Nicoll JA, Esiri MM,
Wong PT, Chen CP, Ramirez MJ, Francis PT. Selective effects
of the APOE epsilon4 allele on presynaptic cholinergic
markers in the neocortex of Alzheimer's disease. Neurobiol Dis. 2006;22(3):555-61.
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Tsang SW, Lai
MK, Kirvell S, Francis PT, Esiri MM, Hope T, Chen CP,
Wong PT. Impaired coupling of muscarinic M1 receptors to
G-proteins in the neocortex is associated with severity of
dementia in Alzheimer's disease. Neurobiol Aging.
2006;27(9):1216-23.
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Garcia-Alloza M,
Tsang SW, Gil-Bea FJ, Francis PT, Lai MK, Marcos B,
Chen CP, Ramirez MJ. Involvement of the GABAergic system in
depressive symptoms of Alzheimer's disease. Neurobiol
Aging. 2006;27(8):1110-7.
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Lai MK,
Tsang SW, Alder JT, Keene J, Hope T, Esiri MM, Francis PT,
Chen CP. Loss of serotonin 5-HT2A receptors in the
postmortem temporal cortex correlates with rate of cognitive
decline in Alzheimer's disease. Psychopharmacology (Berl).
2005;179(3):673-7.
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Lai MK,
Lai OF, Keene J, Esiri MM, Francis PT, Hope T, Chen CP.
Psychosis of Alzheimer's disease is associated with elevated
muscarinic M2 binding in the cortex. Neurology.
2001;57(5):805-11.
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