Dr LIM Yaw Chyn
Current Appointment:
Assistant Professor to Departments of
Pathology and Physiology
Education:
July 1988 |
Diploma in Medical laboratory Technology, National
University of Malaysia, Kuala Lumpur, Malaysia |
September 1992 |
M.Sc. with distinction in Biomedical Sciences, University
of Bradford, Bradford, England |
December 1995 |
Ph.D. in Biomedical Sciences, University of Bradford |
Postdoctoral Training:
| Dec 1995 - June 1996 |
Honorary Research Fellow in Biomedical Sciences, University
of Bradford |
Oct 1996 - June 2000 |
Research Fellow in Pathology (Vascular Research Division),
Brigham and Women’s Hospital, Boston, USA |
July 2000 - March 2003 |
Research Associate in Pathology, Brigham and Women’s
Hospital |
Previous Academic Appointments:
Dec 1995 - June 1996 |
Part-time Lecturer in Department of Biomedical
Sciences, University of Bradford |
October 1996 - June 2001 |
Research Fellow in Pathology, Harvard Medical School, Boston,
USA |
| June 2001 - March 2003 |
Instructor in Pathology, Harvard Medical School |
Research Interests:
The current focus of my laboratory is
on the mechanisms underlying the interactions of tumor cells with
the endothelium. One area of my research is to examine the functional
integrity of adhesion molecules on lymphoma cells. Using immunostaining
techniques and the in vitro parallel plate flow chamber system,
I will correlate the levels of expression of various adhesion molecules
on these neoplastic cells with their abilities to interact with
endothelial adhesion molecules under defined flow conditions. In
a parallel project, I am looking into the expression of sialylated
carbohydrates on various tumor cell types, examining their potential
function as selectin ligands and their role in tumor metastasis.
A third area of my research interest is to identify and characterize
functional heterogeneity between endothelial cells from different
vascular beds. The study involves the development of reliable techniques
to isolate and culture endothelial cells from different vascular
beds/organs and to elucidate any physiological or functional differences,
such as their adhesion molecules expression or chemokine production
profiles in response to pro-inflammatory cytokines stimulation.
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