Dr. Richie Soong

CURRENT APPOINTMENTS

• Assistant Professor (Department of Pathology, NUS)

• Senior Research Scientist (Oncology Research Institute, NUS)

• Head, Translational Interface Core Facility (Oncology Research Institute, NUS)

 

PREVIOUS APPOINTMENTS

• Assistant Professor, Pharmacology & Toxicology and Surgery (joint), University of Alabama at Birmingham, USA (2002-2003)

• Research Instructor, Pharmacology & Toxicology and Surgery (joint), University of Alabama at Birmingham, USA (2002)

• Postdoctoral Fellow, Roche Diagnostics GmbH & University of Regensberg (joint), Germany (1998-2001)

• Research Scientist, Brain and Spine Center, Tan Tock Seng Hospital, Singapore (1998)

ACADEMIC QUALIFICATIONS

• Doctor of Philosophy: Surgery, Obstetrics&Gynaecology, The University of Western Australia (1997)

• Bachelor of Science (1st Class Honours): Biochemistry, The University of Western Australia (1993)

SELECTED PUBLICATIONS (from 28 full-length publications)

• Soong, R., Ladanyi, A. Improved indicators for assessing the reliability of detection and quantification by kinetic PCR, Clinical Chemistry, 49: 973-976, 2003.

• Mattison, L. K., Soong, R., and Diasio, R. B. Implications of dihydropyrimidine dehydrogenase on 5-fluorouracil pharmacogenetics and pharmacogenomics. Pharmacogenomics, 3: 485-492, 2002.

• Soong, R., Beyser, K., Basten, O., Kalbe, A., Rueschoff, J., and Tabiti, K. Quantitative reverse transcription-polymerase chain reaction detection of cytokeratin 20 in noncolorectal lymph nodes. Clin Cancer Res, 7: 3423-3429, 2001.

• Soong, R., Powell, B., Elsaleh, H., Gnanasampanthan, G., Smith, D. R., Goh, H. S., Joseph, D., and Iacopetta, B. Prognostic significance of TP53 gene mutation in 995 cases of colorectal carcinoma. Influence of tumour site, stage, adjuvant chemotherapy and type of mutation. Eur J Cancer, 36: 2053-2060, 2000.

• Iacopetta, B. J., Soong, R., House, A. K., and Hamelin, R. Gastric carcinomas with microsatellite instability: clinical features and mutations to the TGF-beta type II receptor, IGFII receptor, and BAX genes. J Pathol, 187: 428-432, 1999.

• Iacopetta, B. J., Welch, J., Soong, R., House, A. K., Zhou, X. P., and Hamelin, R. Mutation of the transforming growth factor-beta type II receptor gene in right-sided colorectal cancer: relationship to clinicopathological features and genetic alterations. J Pathol, 184: 390-395, 1998.

• Soong, R. and Iacopetta, B. J. A rapid and nonisotopic method for the screening and sequencing of p53 gene mutations in formalin-fixed, paraffin-embedded tumors. Mod Pathol, 10: 252-258, 1997.

• Soong, R., Robbins, P. D., Dix, B. R., Grieu, F., Lim, B., Knowles, S., Williams, K. E., Turbett, G. R., House, A. K., and Iacopetta, B. J. Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas. Hum Pathol, 27: 1050-1055, 1996.

RESEARCH INTERESTS

oncology, pharmacogenetics, pharmacogenomics, molecular subtyping, p53, microsatellite instability, methylation, PCR, molecular assays