Variability in Human Drug Response
It has long been recognized that patients differ substantially in the way they respond to their medications.
These differences may relate to compliance issues or to the way their medications interact with concurrent medications
and other chemicals in their diet. Often differences may reflect the individual genetic makeup in terms of
how the body deals with drugs and exogenous chemicals.
The complex interactions between one's genetic makeup, environment and culture ultimately determine
the balance of health and disease, as well as one's response to drugs.
- Genotyping for drug metabolism enzymes, transporters and ion channels
- Sequencing Ethnic based population (SNP/allele frequencies)
- Phase 1 / Pharmacokinetic studies
- B Lymphocyte immortalization and cryopreservation
Oral sulfasalazine as a clinical BCRP probe substrate: Pharmacokinetic effects of genetic variation (C421A) and pantoprazole coadministration.
J Pharm Sci. 2009; in press.
Identification of functional promoter haplotypes of human concentrative nucleoside transporter 2, hCNT2 (SLC28A2)
Drug Metab Pharmacokinet. 2009; 24: 161-166
The Pharmacogenetics Laboratory was initiated by Professor Edmund Lee with a start-up grant from the National Science and
Technology Board (now known as A*STAR).
It has its origin as a research-based laboratory in the
Department of Pharmacology, dedicated to studying genetic polymorphisms and drug metabolism.
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