The Bioanalytical and Pharmacokinetics Laboratory (Bioanalytical PK Lab) of Department of Pharmacology was initiated more than 20 years ago, as the first Therapeutic Drug Monitoring (TDM) service and research laboratory in Singapore with a generous grant from the Singapore Turf Club. TDM services and research supported by A/Prof Lee How Sung and Clinical Pharmacologists A/Prof Ti Teow Yee (retired) and A/Prof Tan Chay Hoon in the Department were offered to all Singapore hospitals until the hospitals started their own TDM services.

The laboratory then concentrated on clinical pharmacokinetics research by developing and validating bioanalytical methods to quantify drugs and metabolites concentrations in patients’ biological fluids to analyse the pharmacokinetics of the drugs in our local population. Examples of some of the drugs that have been studied included antimicrobials, CNS drugs and more recently oncology drugs. Clinical Pharmacokinetic (PK) studies are correlated with pharmacodynamics (PD). PK and PD parameters are highly variable in different patients. Hence the research objective is to relate all three; PK, PD and pharmacogenetics (PG). The addition of PG to PK/PD has the potential to further optimise therapeutic efficacy and minimise adverse effects of drugs in patients. Current research studies are mainly collaborations with Dr. Boon-Cher Goh and his group at National University Hospital (NUH) Haematology Oncology, Cancer Therapeutic Research Group (CTRG)

The laboratory has also provided services to hospitals, pharmaceutical companies and other research groups on TDM studies, bioequivalence studies, drug transport and distribution studies and other preliminary PK and toxicokinetic (TK) studies in animals...

Last modified on 22 August 2008