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Cubic membrane biogenesis and function(s)
Virus-induced host cubic membrane formation
Cubic membrane: a novel carrier for gene transfection
Academic Background:
Postdoctoral Fellow, Wadsworth Center, NYS Dept. of Health, Albany, NY, 1998-2001
Ph.D., Physiology & Biophysics, State University of New York at Buffalo, 1998
M.Sc., Oral Sciences, State University of New York at Buffalo, 1991
D.D.S., Kaohsiung Medical University, Taiwan, 1988
Career History
2002-present Assistant Professor, Dept. of Physiology, NUS, Singapore
1998-2001 Research Affiliate, Wadsworth Center, NYS Department of Health, USA
Selected Publications:
Deng Y, Almsherqi ZA, Shui GH, Wenk MR, Kohlwein SD (2009). Docosapentaenoic acid (DPA) is a critical determinant of cubic membrane formation in amoeba Chaos mitochondria. (submit to FASEB J)
Almsherqi ZA Landh T. Kohlwein SD, Deng Y (2009). Cubic membranes: the missing dimension of cell membrane organization. International Review of Cell & Molecular Biology vol 274 (in press)
Almsherqi Z, Hyde S, Ramachandrana M, Deng Y (2008). Cubic membranes: a structure-based design for DNA uptake. J R Soc Interface 5:1023-9.
Almsherqi ZA, Kohlwein SD, Deng Y (2006). Cubic membranes: a legend beyond the Flatland of cell membrane organization. J Cell Biol 173:839-44.
Almsherqi ZA, McLachlan CS, Slocinska MB, Sluse FE, Navet R, Kocherginsky N, Kostetski I, Shi DY, Liu SL, Mossop P, Deng Y (2006). Reduced cardiac output is associated with decreased mitochondrial efficiency in the non-ischemic ventricular wall of the acute myocardial-infarcted dog. Cell Res 16:297-305.
Almsherqi Z, McLachlan CS, Mossop P, Knoops K, Deng Y (2005). Direct template matching reveals a host subcellular membrane gyroid cubic structure that is associated with SARS virus. Redox Report 10:167-71.
Deng Y, Kohlwein SD, Mannella CA (2002). Fasting induces cyanide-resistant respiration and oxidative stress in the amoeba Chaos carolinensis: Implications for the cubic structural transition in mitochondrial membranes. Protoplasma 219:160-7.
Deng Y, Marko M, Buttle KF, Leith A, Mieczkowski M, Mannella CA (1999). Cubic membrane structure in amoeba (Chaos carolinensis) mitochondria determined by electron microscopic tomography. J Struct Biol 127:231-9. (cover photo)
Deng Y, Mieczkowski M (1998). Three-dimensional periodic cubic membrane structure in mitochondria of amoeba Chaos carolinensis. Protoplasma 203:16-25.
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