Research Interests:

Molecular Cytogenetics

Telomeres and DNA repair factors in ageing and cancer

Mechanisms and Impact of Chromosome Abnormalities

Telomere dysfunction and chromosome instability in tumorigenesis

Academic Background: 

Associate Research Scientist, Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, USA, 2000-2002. 

Postdoctoral Fellow, The Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada, 1997-2000. 

Postdoctoral Fellow, Department of Radiation Genetics, Leiden University, Leiden, The Netherlands, 1994-1997 

Monbusho Scholar (Japanese Government Scholarship) Department of Radiation Biology, Faculty of Medicine, Osaka University, Osaka, Japan, 1993-1994 

Assistant Professor in the Department of Radiobiology, Kasturba Medical College, Manipal, India, 1991-1992 

Ph.D., Radiobiology, Kasturba Medical College, Mangalore University, India, 1991.

M.Sc., Zoology (Reproductive Biology), University of  Mysore, India, 1986.

B.Sc. Botany, Zoology and Chemistry, Bhandarkar’s College, Kundapur, Mangalore University, India, 1984.

Selected Latest Publications: 

Ting APL, Low GKM, Hande MP 2009 Genomic instability and telomere attrition in Xeroderma Pigmentosum- B deficient fibroblasts under oxidative stress. Journal of Cellular and Molecular Medicine (in press).

Poonepalli A, Banerjee B, Ramanarayan K, Palanisamy N, Putti TC, Hande MP 2008 Telomere mediated genomic instability correlates with the clinico-pathological parameters of breast cancer. Genes Chromosomes and Cancer, 47: 1098-1109.

McPherson JP*, Hande MP†*, Poonepalli A, Lemmers B, Matysiak-Zablocki E, Migon E, Shehabeldin A, Porras A, Karaskova J, Vukovic B, Sanchez-Sweatman OH, Squire J, Hakem R†. 2006 A role for Brca1 in chromosome end maintenance, Human Molecular Genetics, 15 (6): 831-838.

Poonepalli A*, Balakrishnan L*, Khaw AK, Low GKM, Jayapal M, Bhattacharjee RN, Akira S, Balajee AS, Hande MP† 2005 Lack of poly(ADP-ribose) polymerase – 1 (PARP-1) gene product enhances cellular sensitivity to arsenite. Cancer Research, 65: 10977-10983.

McPherson JP, Lemmers B, Chahwan R, Pamidi A, Migon E, Matysiak-Zablocki E, Moynahan ME, Essers J, Hanada K, Poonepalli A, Sanchez-Sweatman, Khokha R, Kanaar R, Jasin M, Hande MP, Hakem R (2004) Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science, 304 (5678): 1822-1826.

Hande MP, TV Azizova, CR Geard, LE Burak, CR Mitchell, VF Khokhryakov, FK Vasilenko and DJ Brenner (2003) Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. American Journal of Human Genetics, 72: 1162-1170.

d’Adda di Fagagna F*, MP Hande*, WM Tong, PM Lansdorp, ZQ Wang and SP Jackson (1999) Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nature Genetics, 23: 76-80.

*equal contributions; †Corresponding authors