Research Interests:

Role of proline rich acidic protein and heparan/heparin sulfate interacting protein in colon cancer cell proliferation

Role of histone deacetylases in cancer

Genes involved in colon cancer metastasis

Academic Background:

Ph.D., Harvard – 1987-92

M.B.B.S, NUS - 1978-83

Selected Publications:

Liu J-J, BH Huang and SC Hooi (2006) Acetyl-keto-b-boswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells, British Journal of Pharmacology (in press).

Tan HT, RM Zubaidah, S Tan, SC Hooi and MCM Chung (2006) 2-D DIGE analysis of butyrate-treated HCT-116 cells after enrichment with heparin affinity chromatography, Journal of Proteome Research, 5(5): 1098-1106.

Liu J-J, BH Huang, J Zhang, Carson, DD and SC Hooi (2006) Repression of HIP/RPL29 expression induces differentiation in colon cancer cells, Journal of Cellular Physiology, 207: 287-292.

Tan EH, SC Hooi, M Laban, E Wong, S Ponniah, A Wee and ND Wang (2005) CCAAT/Enhancer binding protein a knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma, Cancer Research, 65(22): 10330-10337.

Huang BH, M Laban, CH Leung, L Lee, CK Lee, M Salto-Tellez, GC Raju and SC Hooi. (2005) Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1. Cell Death and Differentiation, 12: 395-404.

Liu J, J Zhang, S Ramanan, J Julian, DD Carson and SC Hooi (2004) Heparin/heparan sulfate interacting protein plays a role in apoptosis induced by anticancer drugs. Carcinogenesis, 25: 873-879

Zhang J, H Wong, S Ramanan, D Cheong, A Leong and SC Hooi. (2003) The proline rich acidic protein is epigenetically regulated and inhibits growth of cancer cell lines. Cancer Research, 63(20): 6658-6665.

Tan SBE, TK Seow, RCMY Liang, CPC Lee, MCM Chung and SC Hooi (2002) Proteomic analysis of proteins regulated by butyrate treatment of HT-29 human colon cancer cells. International Journal of Cancer, 98(4): 523-531.

Wang Y, D Cheong, S Chan and SC Hooi (1999) Heparain/heparan sulfate interacting protein gene expression is up-regulated in human colorectal carcinoma and correlated with differentiation status and metastasis. Cancer Research, 59: 2989-2994.