Research Interests:

Functional integrity of adhesion molecules on lymphoma cells

Mechanisms underlying the interactions of tumor cells with the endothelium

Immunomodulation of the tumor microenvironment by pro-inflammatory and anti-inflammatory mediators

Key mediators that regulate the recruitment of mesenchymal stem cells to peripheral injury sites

Academic Background:

Ph.D. (Biomedical Sciences), University of Bradford, UK, 1995

M.Sc. with Distinction (Biomedical Sciences), University of Bradford, UK, 1992

Diploma (Medical Laboratory Technology), National University of Malaysia, 1988

 

Selected Publications:

Lim Y-C, G Garcia-Cardena, JR Allport, M Zervoglos, AJ Connolly, MA Jr Gimbrone and FW Luscinskas (2003) Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. American Journal of Pathology, 162: 1591-1601.

Garbie N, MW Delfs, Y-C Lim, JR Westrich, FW Luscinskas and AH Lichtman (2002) ST3Gal-I sialyltransferase gene expression during Th2 but not Th1 differentiation: implications for core2-glycan formation on cell surface proteins. European Journal of Immunology, 32: 2766-2772.

Lim Y-C, H Xie, CE Come, SI Alexander, MJ Grusby, AH Lichtman and FW Luscinskas (2001) IL-12, STAT4 dependent upregulation of CD4+ T cell core2 b-1, 6-N-acetylglucosaminyltransferase (C2GnT), an enzyme essential for biosynthesis of P-selectin ligands. Journal of Immunology, 167: 4476-4484.

Lim Y-C, M Wakelin, L Henault, DJ Goetz, TA Yednock, C Cabanas, F Sanchez-Madrid, AH Lichtman and FW Luscinskas (2000) a4b1 integrin activation is necessary for high efficiency T cell subset adhesion to VCAM-1 under flow. Microcirculation, 7: 201-214.

Xie H, Y-C Lim, FW Luscinskas and AH Lichtman (1999) Acquisition of selectin binding and peripheral homing properties by CD4+ and CD8+ T cells. Journal of Experimental Medicine, 189: 1765-1775.