Research Interests:

Regulation Of T Cell/B Cell Function and Apoptosis: Importance In The Development Of Asthma. 

Differential Tumor Infiltrating Leukocyte Function Influencing Cancer Development and Progression. 

Molecular Mechanisms Of Cancer Cell Movement and Migration. 

Novel Signaling Partners Involved In Inflammation and Cancer. 

MicroRNAs In Cancer and Inflammation. 

Identification Of Novel Chemicals/Drugs For Use In The Treatment Of Cancer/ Asthma.

Academic Background:

Research Fellow, Johns Hopkins University, Baltimore, USA, 2003

PhD. Immuno-pharmacology, St Bartholomew's Hospital Medical School, London, UK, 2000

B.Sc, (Hons). Pharmacology, Kings College London, UK, 1996

Selected Publications:

Kong K, Leong WK, Lim LHK. Osmium carbonyl clusters containing labile ligands hyper-stabilizes microtubules. Chemical Research in Toxicology 2009 22(6):1116-1122

Ang ZF, Sim HL, Nguyen TH, Putti TC, Lim LHK. Annexin-1 regulates growth arrest induced by high levels of estrogen in MCF-7 breast cancer cells. Mol Cancer Res 2009 7:266-274

Tan YW, Lim LHK. Anti-inflammatory effects of Resveratrol on human eosinophils. Br J Pharmacol. 2008 Dec;155(7):995-1004.

Lim LHK and EM Wagner (2003) Airway distension promotes leukocyte recruitment in rat tracheal circulation. Am J Respir Crit Care Med., 168(9): 1068-1074. With editorial: Uhlig S. Taking a peep at the upper airways. Am J Respir Crit Care Med., 168(9): 1026-1027. 

Lim LHK, BS Bochner and EM Wagner (2002) Leukocyte recruitment in the airways: an intravital microscopy study in the rat tracheal microcirculation. Am J Physiol Lung Cell Mol Physiol, 282(5): L959-967. With editorial: Taylor AE, T Moore and P Paisley (2002) The time has finally arrived: use of intravital microscopy in the airway circulation. Am J Physiol Lung Cell Mol Physiol, 282(5): L957-958.

Henderson RB*, LHK Lim, PA Tessier, FNE Gavins, M Mathies, M Perretti and N Hogg (2001) The use of LFA-1 deficient mice to determine the role of LFA-1, Mac-1 and a4 integrin in the inflammatory response of neutrophils. J. Exp Med., 194(2): 219-226.

Lim LHK, E Solito, F Russo-Marie, RJ Flower and M Perretti (1998) Detachment of leukocytes adherent to murine post-capillary venules as a novel target to control inflammation: effect of lipocortin 1. Proc. Natl. Acad. Sci. USA, 95: 14535-14539.

Szabo C, LHK Lim, S Cuzzocrea, SJ Getting, B Zingarelli, RJ Flower, AL Salzman and M Perretti (1997) Inhibition of poly (ADP-ribose) Synthetase attenutates neutrophil recruitment and exerts anti-inflammatory effects. J Exp Med, 186: 1041-1049.