Research Interests:

SUMO-mediated repression of orphan nuclear receptors by DEAD-box proteins. 

Nuclear receptors in physiology and disease of the kidney and endocrine organs.

Academic Background:

2004: PhD, Biomedical Sciences Graduate Program, University of California, San Francisco

1995-1997: Nephrology Resident, Singapore General Hospital

1995: M.R.C.P. (UK),

1988: M.B.B.S., Faculty of Medicine, National University of Singapore

Selected Publications:

Tran, P.V., Lee, M.B., Marin, O., Xu, B., Reichardt, L.F., Jones, K.R., Rubenstein, J.R. and Ingraham H.A.. Requirement of steroidogenic factor-1 in terminal differentiation of ventromedial hypothalamic neurons.  Molecular and Cellular Neuroscience 22(4):441-53 (2003).

Lee, Martin B, Lioudmila A Lebedeva, Phu V Tran, Marion Desclozeaux, Robert C Fowkes, Miyuki Suzawa, and Holly A Ingraham.  The DEAD-box protein DP103 (Ddx20, Gemin-3) represses orphan nuclear receptor activity via SUMO-modification. In press, Molecular and Cellular Biology 2004.