Research Interests:
Regulation of skeletal myogenesis, and adipogenic cell differentiation
Regulation of apoptosis and cellular stress response
Academic Appointments:
2008-present
Associate Professor, Dept. of Physiology, NUS, Singapore
2008-present
Adjunct Associate Professor, Mount Sinai School of Medicine, New York.
http://www.mountsinai.org/Find%20A%20Faculty/profile
2007-present
Member, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York.
http://www.blackfamilystemcell.org/BFSCIresearch.html
2002-2008
Associate Professor, Mount Sinai School of Medicine, New York
1997-2002
Assistant Professor, Mount Sinai School of Medicine, New York
Academic Background:
Postdoctoral fellow: With Prof. Pierre Chambon, IGBMC, Strasbourg, France, 1992-1997
Ph.D: Indian Institute of Science, India. 1987-1992
M.Sc: MS University, India, 1984-1987
B.Sc: MG Science College, India, 1981-1984
Selected Publications:
Vercherat C, Chung T-K, Yalcin S, Gulbagci N, Gopinadhan S, Ghaffari S and Taneja R. (2009, in press). Stra13 regulates oxidative stress mediated skeletal muscle degeneration. Human Molecular Genetics
Pervaiz S, Taneja R, Ghaffari S. (2009, in press) Oxidative Stress Regulation of Stem and Progenitor Cells. Antioxidants and Redox Signaling
Gulbagci NT, Li L, Ling B, Gopinadhan S, Walsh M, Rossner M, Nave KA, Taneja R. (2009). SHARP1/DEC2 inhibits adipogenic differentiation by regulating the activity of C/EBP. EMBO Reports. 10:79-86.
Rossner MJ, Oster H, Wichert SP, Reinecke L, Wehr MC, Reinecke J, Eichele G, Taneja R, Nave KA. (2008). Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice. PLoS ONE. 3(7):e2762.
Yalcin S, Zhang X, Luciano JP, Mungamuri SK, Marinkovic D, Vercherat C, Sarkar A, Grisotto M, Taneja R, Ghaffari S. (2008). Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells. J Biol Chem. 283:25692-705
Sun, H., Ghaffari, S., and Taneja, R. (2007). bHLH-Orange transcription factors in development and cancer. Translational Oncogenomics 2: 105-118.
Sun. H., Li, L., Vercherat, C., Gulbagci, N., Acharjee, S., Li, J., Chung, T-K., Thin. T., and Taneja, R. (2007). Stra13 regulates satellite cell activation by antagonizing Notch signaling. J. Cell Biol 177:647-57.
Thin, T., Li, L., Chung, T-K, Sun, H., and Taneja, R(2007). Stra13 is induced by genotoxic stress and is required for ionizing radiation induced apoptosis. EMBO Reports 8:401-407.
Sun, H. and Taneja, R.(2007)Analysis of transformation and tumorigenesis using mouse embryonic fibroblast cells. In: Methods in Molecular Biology, P. Fisher (ed.) Humana Press Inc, Totowa, NJ. pp 303-310.
Sun, H., Gulbagci N., and Taneja R.(2007) Analysis of growth properties and cell cycle regulation using mouse embryonic fibroblast cells. In: Methods in Molecular Biology. P. Fisher, (ed.) Humana Press Inc, Totowa, NJ. pp 311-319.
Taneja, R. Editor (2006). Nuclear Receptors in Development. In: Advances in Developmental Biology , Elsevier Press, Amsterdam 411 pages
Bour, G., Taneja, R., and Rochette-Egly, C. (2006). Mouse Embryocarcinoma F9 cells and Retinoic Acid: A model to study the molecular mechanisms of endodermal differentiation. In: Advances in Developmental Biology. R. Taneja (ed.) Elsevier Press, Amsterdam pp. 212-240
Kupumbati, T.S., Cattoretti, G., Marzan, C., Farias, E.F., Taneja, R., Mira-y-Lopez R. (2006) Dominant negative retinoic acid receptor initiates tumor formation in mice. Mol Cancer 5:12.
Taneja, R. Nuclear receptors. Sci. STKE 2005 May 31;2005(286):tr17.
Azmi, S., Ozog, A and Taneja, R. (2004). Sharp-1 inhibits skeletal muscle differentiation through repression of myogenic transcription factors. J. Biol. Chem 279: 52643-52652
Azmi, S., Sun, H., Ozog., A and Taneja, R. (2003). mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E-box activity and Stra13 expression. J. Biol. Chem. 278: 20098-20109.
Azmi, S. and Taneja, R.(2002). Embryonic expression of mSharp-1/mDEC2, which encodes a bHLH transcription factor. Mechanisms of Development 114:181-185.
Sun, H., Lu, B., Li, R-Q, Flavell, R.A. and Taneja, R. (2001). Defective T-cell activation and autoimmune disorder in Stra13-deficient mice. Nature Immunology 2: 1040-1047.
Dhar, M and Taneja, R. (2001). Cross regulatory interaction between Stra13 and USF results in functional antagonism. Oncogene 20: 4750-4756.
Sun, H and Taneja, R. (2000). Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC) dependent and HDAC independent mechanisms. Proc. Natl. Acad. Sci (USA) 97: 4058-4063.
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