Research Interests:

Functional analysis of Cancer susceptibility genes

Hormonal interactions of BRCA2

Molecular and Pathologic classification of BRCA unclassified variants

Rapid generation of multiple alleles by Recombineering

Role of ATM in BRCA or non-BRCA cancer susceptibility

Academic Background:

Ph.D., National Institute of Immunology, Jawaharlal Nehru University, New Delhi, India.

M.Sc., Bangalore University, Bangalore, India.

B.Sc. (Hons.), Delhi University, New Delhi, India.

Selected Publications:

Chaw KC, Manimaran M, Tay FEH and Swaminathan S (2007) Matrigel coated polydimethylsiloxane based microfluidic devices for studying metastatic and non-metastatic cancer cell invasion and migration. Biomedical Microdevices Epub 10.1007/s10544-007-9071-5.

Senatorov V, Malyukova I, Fariss R, Wawrousek E, Swaminathan S , Sharan SK , Tomarev S (2006) Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice. Journal of Neuroscience 26(46):11903-14.

Chaw KC, Manimaran M, Tay FE and Swaminathan S (2006) A quantitative observation and imaging of single tumor cell migration and deformation using a multi-gap microfluidic device representing the blood vessel . Microvascular Research 72(3):153-160.

SwaminathanS and Sharan SK (2004) Bacterial Artificial Chromosome engineering. Methods in Mol. Biol. 256 (2): 89-106, eds. S. Zhao and M. Stodolsky, Humana Press Inc., NJ.

Sharan SK, Pyle A, Coppola V, Babus J, Swaminathan S, Benedict J , Swing D , Martin BK , Tessarollo L , Evans JP , Flaws JLand Handel MA (2004) BRCA2 deficiency in mice leads to meiotic impairment and infertility. Development 131: 131-142.

Yang Y, Swaminathan S, Martin BK, Brody LC, Sharan SK (2003) Aberrant splicing induced by missense mutations in BRCA1: Clues from a humanized mouse model. Human Molecular Genetics 12 (17): 2121-2131.

Court DL, Swaminathan S, Yu D, Wilson H, Baker T, Bubunenko M, Sawitzke J, Sharan SK (2003) Mini-lambda: A tractable system for genomic engineering. Gene 315: 63-69.

Kraakman-van der Zwet M, Overkamp WJI, Van Lange REE, Essers J, Van Duijn-Goedhart A, Wiggers I, Swaminathan S, et al (2002) Brca2 (XRCC11) deficiency results in enhanced mutagenesis and radioresistant DNA synthesis. Mol. Cell. Biol. 22 (2): 669-679.

Swaminathan S , Ellis HM, Waters LS, Yu D, Lee E-C, Court DL, Sharan SK (2001) Rapid engineering of bacterial artificial chromosomes using oligonucleotides. Genesis 29: 14-21.