Research Interests:

Metabolic biology of Alzheimer's disease .

ApoE biology in Alzheimer's disease .

For more information, please visit our lab webpage.

Academic Background:

1999 PhD NERC Institute of Virology and Environmental Microbiology, Oxford (now CEH Oxford), and the Open University, UK.

1995 BSc Queen's University of Belfast, UK.

Selected Publications:

Goh, A. X., Li, C, Sy, M-S. and Wong, B-S. (2007). Altered prion protein glycosylation in the ageing mouse brain. J Neurochem100(3):841-854.

Pan, T., Li, R., Kang, SC, Pastore, M., Wong, B-S., Ironside, J., Gambetti, P. and Sy, M-S. (2005). Biochemical fingerprints of prion diseases: scrapie prion protein in human prion diseases that share prion genotype and type. J Neurochem92(1):132-142.

Kang, S-C., Brown, D.R., Whiteman, M., Li, R., Pan, T., Perry, G., Wisniewski, T., Sy, M-S. and Wong, B-S. (2004). Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice. J Pathol203(1):603-608.

Kang, S-C., Li, R., Wang, C., Pan, T., Liu, T., Rubenstein, R., Barnard, G., Wong, B-S. and Sy, M-S. (2003). Guanidine hydrochloride extraction and detection of prion proteins in mouse and hamster prion diseases by ELISA. J Pathol199(4):534-541.

Wong, B-S., Brown, D.R., Pan, T., Whiteman, M., Liu, T. Bu, X., Li, R., Gambetti, P., Olesik, J., Rubenstein, R. and Sy, M-S. (2001). Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered anti-oxidation activities. J Neurochem79(3):689-698.

Wong, B-S., Green, A.J.E., Li, R., Xie, Z., Pan, T., Liu, T., Chen, S.G., Gambetti, P. and Sy, M-S. (2001). Absence of protease resistant prion protein in the cerebrospinal fluid of Creutzfeldt-Jakob disease. J Pathol194 (1):9-14.