Voltage-gated calcium channels are hetero-oligomeric transmembrane protein complexes that play a role in neurotransmitter release, muscle contraction, hormone secretion and gene expression. Systematic determination of alternative splice forms of the human P/Q-type and L-type voltage gated calcium channels revealed a potentially rich source of functional diversity. Investigations of the electrophysiological and pharmacological properties of these variants will add to our understanding of the fine-tuning of activity-dependent performances of these channels