Liver Tissue Engineering & Bio-Imaging Projects

With the advanced cell technologies developed in our group, we embark on the journey of micro-fabricating scaffolds and micro-channels and developing other enabling technologies to build complex tissues such as liver pieces with both structures and functions that mimic or surpass those found in situ. We also take advantages of the sophisticated optical microscopy systems available in the group to observe and quantify tissue regeneration and construct integration in animal tissues and organs.

• Micro-fabricate multidimensional scaffolds for hepatocytes and stem/progenitor cell co-cultures
• Precise control of cell-cell and cell-substrata interaction
• Bio-artificial liver-assisted devices
• Use of non-linear optics and other modalities to image and quantify tissue dynamics intra-vitally
• Preservation and storage of hepatocytes, microencapsulated hepatocytes and bioreactors
• Other relevant projects can be found at http://www.ibn.a-star.edu.sg

Collaborators and Team Members

• Hanry Yu (Principal Investigator)
• Khong Yuet Mei (Ph.D. candidate)
• Ng San San, Susanne (Ph.D. candidate)
• Toh Yi Chin (Ph.D. candidate)
• Toh Yi Er (Lab Officer- Software Engineering)
• Wang Xianwei (Lab Officer- Surgery)
• Wu Yingnan (M.Sc. student)
• Zhang Jing (Lab officer- Chemistry)
• Zhou Yi (Research Assistant- Image Processing)
• Zhu Jian-Hang (Research Fellow- Bioreactor)
• Several Post-doctoral positions and Graduate Student vacancies are available for applicants with background in Cell/Molecular Biology, Micro-fabrication, Optical Microscopy, or Polymer Synthesis/Biomaterials Research
• Chen Jia Ping, Paul (Engineering, NUS)
• Ping Chin Cheng (Buffalo)
• Lilia Kuleshova (NUMI, NUS)
• Kam W. Leong (Johns Hopkins University)
• Mao Hai Quan (Johns Hopkins University)
• Ng Soon Chye (O&G, NUH)
• Partha Roy (Bioengineering, NUS)
• Victor Samper (IBN, A*STAR & Bioengineering, NUS)
• Teoh Swee Hin (ME, NUS)
• Zhuo Lang (IBN, A*STAR)