Cell Motility and Cytoskeleton
To precisely control the macromolecule delivery for targeted drug delivery
and gene therapy, we are dissecting some of these molecular complexes that drive
and regulate the intra-cellular dynamics. A combination of molecular biology,
protein chemistry, video-enhanced light microscopy at high resolution and sensitivity,
laser-scanning confocal microscope-based 4-D live cell imaging, are employed
in a number of in vitro and in vivo assays to identify and characterize components
of these molecular complexes and to understand their functions.
- Characterization of the kinectin-associated proteins & their roles in
regulating the intra-cellular dynamics
- Understanding the functions of kinectin isoform family
- Investigating how the dynamics of endoplasmic reticulum can regulate
protein synthesis and processing
Collaborators and Team Members
- Hanry Yu (Principal Investigator)
- Lee Kong Heng (Lab Officer- Microscopy)
- Lin Pao Chun (University Scholar)
- Ong Lee Lee (Ph.D. candidate)
- Tan Yee Ling (Lab Officer- Molecular Biology)
- Zhou Yi (Research Assistant- Image Processing)
- Zhu Yajuan (M.Sc. student)
- One Ph.D. student vacancy available
- Ping Chin Cheng (Buffalo)
- Gareth Griffiths (EMBL)
- Sergei Kuznetsov (Heidelberg)
- Niovi Santama (Cyprus)
- Mike Sheetz (Columbia University)